Abstract: Mesenchymal stem cells are multipotent stem cells,they have specific immune characteristics,for example,they could suppress activation of T cells and modulate immune tolerance of allogeneic transplants. Liver transplantation is the primary treatment for various end-stage hepatic diseases but is hindered by the lack of donor organs and by complications associated with rejection and immunosuppression. Studys have shown that bone marrow is one of transplantable source of hepatic progenitors. Multipotent bone marrow-derived mesenchymal stem cells can differentiate into functional hepatocyts,secrete related cytokines promoting regeneration of the hepatocytes under defined conditions, it provides a new way for treating kinds of liver injury.The function of mesenchymal stem cells for hepatic disease is discussed in this review.