Abstract: Objective To investigate the clinical feature, diagnosis and therapy of giant hypertrophy gastritis. Methods We reported a case of giant hypertrophy gastritis with hypoproteinemia secondary to a loss of albumin into the gastric lumen. The diagnosis of giant hypertrophy gastritis was made by using a combination of radiologic examination, endoscopic imaging, and histologic analysis. Glucocorticoid treatment was given to the patient. Through literature review, the clinical and pathological features, diagnosis, therapy of giant hypertrophy gastritis were overviewed. Results Endoscopic and radiologic examination revealed enlarged gastric folds on the body of stomach. Endoscopic sonography revealed marked thickening of mucosal layer on the body of stomach and gastric fundus. Pathologic findings are consistent with giant hypertrophy gastritis. After glucocorticoid treatment, hypoproteinemia resolved. Conclusion　Giant hypertrophy gastritis may be responsive to glucocorticoid. Understanding of this disease should be improved to avert misdiagnosing.

Key words: giant hypertrophy gastritis, protein-losing gastropathy, hypoproteinemia, glucocorticoid.