Abstract: Objective: This study was to explore the function reestablishment patterns of neuroimmunoregulation network. Methods: Whole-some gene array was performed to analyze the genes expression difference involved in neuroimmunoregulation function of the lateral hypothalamic (LH) in rats at different immunizational time. The function trees of different genes were analysed with the PathWay Miner public database. Results: 632 of the genes were considered to be differentially expressed in comparison to the control group: 374 of 2-day immunized group，62 of 4-day immunized group ，and 196 of 6-day immunized group. Function signal pathway analysis for 398 up-regulated genes shows 27 genes evolved in 31 cell functional signal conduction pathways, including the well-known signal conduction pathways of synaptic reconstruction. Conclusions: Synapses reconstruction appears to be the important pattern of function reestablishments in neuroimmunoregulation network.

Key words: neuroimmunoregulation network, synapse plasticity, neuron regeneration, function reconstruction of network