Abstract: Objective To observe the effects of VEGF antisense oligonucleotide on growth of micrangium of xenograft in nude mice. Methods: The VEGF-ASODN was synthesised artificially..After transfection with VEGF-ASODN, RNA copies was detected by real-time PT-PCR ,VEGF PROTEIN was detected by ELESA, Survival of cells was detected by MTT.Growth of cells was evaluated by growth curve. After the model of human gastic cancer xenografts in nude mice were founded,they were distributed randomly into three groups:antisense group、scrambled group and saline group. We established control group . Results ：VEGF-ASODN can reduce the VEGFmRNA and VEGF PROTEIN in cells and supernate remarkably . Survival and growth of cells was suppressed. It can reduce VEGF PROTEIN in serum of nude mice significantly . It can also reduce the volum and weight of xenografts.Density of micrangium decreased in xenografts. Conclution VEGF-ASODN can suppressed the growth of micrangium in xenografts.