Abstract: Objective To study the effect of fusion protein FADDDEL-GFP in the treatment of type 1 diabetes by islet cell transplantion. Methods After transfecting the recombinate FADDDEL-GFP into mouse insulinoma cells NIT-1, insulin level secreted by the cells was detected. Type 1 diabetes model was induced by STZ. NIT-fg cells, the NIT-1 cells modified by FADDDEL-GFP, were transplanted into the diabetic mice. Then the effects of islet cell transplantation on diabetic mice were detected. Results GFP was expressed in NIT-1 cells transfected with FADDDEL-GFP. Diabetic mice reached normoglycemia and prolonged the life span, which is different obviously from the control group. ConclusionsFADDDEL-GFP could enhance the capability of resisting allogeneic transplantation rejection.