Abstract: Delayed wound healing in diabetic cornea may be associated with the activation of MAPK signal pathway, impaired signal transduction of TGF-β signal pathway, abnormal expression of genes related to insulin signal pathway and reduced expression of insulin receptor. In addition, the activation of NF-κb and cytochrome C signal pathway also has harmful influence on delayed wound healing. This paper reviews research progress about signal pathway of delayed wound healing in diabetic cornea.

Key words: Signal pathway, corneal wound healing, diabetes mellitus