Effects of transplantation of MSCs on the key enzymes of energy metabolism in acute myocardial infarction rat

Basic & Clinical Medicine ›› 2009, Vol. 29 ›› Issue (3): 238-241.

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Effects of transplantation of MSCs on the key enzymes of energy metabolism in acute myocardial infarction rat

Wang LI, Sheng-shou HU, Ying-jie WEI, Hao ZHANG, Jian-feng HOU, Bo YE

Cardiovascular Institute and Fu-Wai Hospital, PUMC & CAMS Cardiovascular Institute and Fu-Wai Hospital, PUMC & CAMS Cardiovascular Institute and Fu-Wai Hospital, PUMC & CAMS Cardiovascular Institute and Fu-Wai Hospital, PUMC & CAMS

Received:2008-06-19 Revised:2008-07-31 Online:2009-03-25 Published:2009-03-25
Contact: Ying-jie WEI,

Abstract

Abstract: Objective To investigate the effects of transplantation of MSCs on the key enzymes of energy metabolism after acute myocardial infarction(AMI). Methods Eighteen SD rats were randomly divided into 3 groups(n=6 respectively):control group,acute myocardial infarction group,MSCs group. The left ventricular tissues of rats were isolated one day later after left anterior descending artery occlusion for determination of HK, CACT,ACS,CS,LDH by ELISA. Result One day post-AMI,the concentration and activity of these enzymes changed obviously（P<0.05～P<0.01）. One day after MSCs treatment post-AMI,some of concentration and activity of those enzymes had returned to normal levels. Conclusion The transplantation of MSCs may improve cadiocyte's energetics by regulating the concentration and activity of those key enzymes .

Key words: mesenchymal stem cells, transplantation, myocardial infarction, key enzymes

CLC Number:

R542.22

Wang LI; Sheng-shou HU; Ying-jie WEI; Hao ZHANG; Jian-feng HOU; Bo YE. Effects of transplantation of MSCs on the key enzymes of energy metabolism in acute myocardial infarction rat[J]. Basic & Clinical Medicine, 2009, 29(3): 238-241.

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Effects of transplantation of MSCs on the key enzymes of energy metabolism in acute myocardial infarction rat

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