Abstract: Objective To determine the expression of CGRP in congenital pseudarthrosis of tibia(CPT),in order to study the cause and pathogenesis of CPT.Method periosteum and bones taken from CPT patients were as experimental group,and those taken from normal persons were as control group.Immunohistochemistry stain were applied to determine the differences of the expression of CGRP in two groups.Results CGRP was located at vessel wall in periosteum and intracytoplasm of osteoblasts and osteoclasts in bones,its expressions were less both in periosteum and bones of CPT than that in control group,and the differences were significant(P<0.05).Conclusion anormaly expression of CGRP in CPT may be one of the causes of CPT.

Key words: Calcitoningene related peptide（CGRP）, Congenital, Pseudarthrosis, Tibia