Abstract: Proteomic technology widely used to research differently expressed proteins under different physiology and pathologic state. In the aspect of the human spermatozoa proteomics, many scholar have researched the differently expressed proteins under physiology and pathologic state by modern proteomics technology, revealed the change rule of sperm under different physiology and pathologic state from proteome level, and provided reliable theoretic base for deeply understand sperm molecule mechanism of physiology and pathologic state.

Key words: Spermatozoa, proteomics