Abstract: Apoptosis induced by P53 gene is one of the most important mechanisms of signal integration in cells，which identify the cell injury and start downstream apoptotic signals. PIG7 gene is induced by P53 and correlates with metabolism, inflammation and tumor. In this review, we mostly described the recent findings in the molecular biology of PIG7 gene and the correlation with human diseases.

Key words: P53, PIG7, LITAF, SIMPLE, Regulation of gene expression, Charcot-Marie-Tooth Disease, IBD, Carcinoma.