Abstract: Systemic Sclerosis(SSc) is a fibrotic disease characterized by immunological abnormalities，vascular injury and increased accumulation of extracellular matrix. The etiology has not been fully elucidated yet, so we need to establish a suitable animal model for research. This review is to introduce murine models of bleomycin-induced SSc, and summarize research works on the pathogenesis and treatment of SSc based on this model.