Abstract: The ApoE and LDL-R knock out mouse may developed atherosclerosis spontaneously and were applied to research on atherosclerosis widely. On the basis of these mouse model, the model generated by gene targeting , like IL-1, C-reactive protein, scavenger receptor, IgG Fc,C1q and CD44, have played an important role in studing effects of inflammatory factor and immune factor on atherosclerosis.

Key words: knock-out mice, atherosclerosis, pathogenic mechanism