Abstract: Objective: To analyze the CT appearance of solid-pseudopapillary tumor of pancreas (SPTP) and enhance the accurate diagnostic rate Methods: 21 patients with surgically and pathologically confirmed SPTP were reviewed. All cases underwent unenhanced spiral scanning CT and three phases post-contrast scanning. The CT imaging were analyzed in comparison with surgical pathological features. Results: Thirteen cases were located in pancreatic head， 8 located in pancreatic body and tail .The diameter of tumors were 2～15cm， 19 were well-circumscribed and encapsulated， most tumor including cystic and solid portion ， the largest diameter of cyst was 4cm， the wall thickness were 0.2～3cm， only 2 were completely solid; The pancreatic head tumors did not cause pancreatic duct and common bile duct dilate obviously. The unenhanced CT scanning showed that tumors were non-homogeneous .On post-contrast CT， the solid portion were slightly enhanced in the arterial phase and markedly enhanced in portal and delay phase. Conclusions: CT was helpful in diagnosing SPTP，the appearance of CT was based on pathology.