Abstract: The application of molecular biological technique provides the only hope to pancreatic cancer patients for the cancer's resistance to conventional treatment. Clarifying the molecular mechanism in the genesis and development of pancreatic cancer is the first thing to do. Recent researches found that there were different signaling pathways activated in different stages of pancreatic cancer. The important signal pathways included mitosis pathways, growth factor pathways, developing pathways and mucin pathways. This article will review on the relationship between molecular pathways and pancreatic cancer.