Abstract: Objective To evaluate the association of c-erbB-2 protein expression with the prognosis of gastric carcinoma. Methods 11 Literatures was analyzed quantitively which published last 15 years on the relationship of c-erbB-2 with prognosis by software RevMan. Results The pooled odds ratio(OR) of 5-year survival rates was 0.69（95%CI：0.54－0．87）for all 11 literatures. The pooled odds ratio(OR) of three literatures from eleven literatures was 0．67（95％CI：0．48－0．94）which 5-year survival rates was determined as final index and OR as associated．For well-differentiated and advanced gastric carcinoma, the pooled odds ratio(OR) of 5－year survival rates were 0．18（95％CI：0．09－0．38）and 0.72(95％CI：0.47－1.09)respectively．Conclusion The association of c-erbB-2 expression with prognosis of gastric carcinoma may be negative．