Abstract: Objective To investigate the correlation of HLA class I and II alleles in a Northern Chinese Family members with psoriasis vulgaris. Methods The polymerase chain reaction amplification with sequence-specific oligonucleotide probe (PCR-SSO) method was used to analysis the alleles of HLA-A,B,DRB1 in all the family members. Results HLA-B*13-DRB1* 07 was identified as a high-risk haplotype in the four early-onset psoriatic members (II-2,II-4, III-1,III-5) (age of onset <40y); while HLA-A*11-B*15-DRB1*15 was identified as a susceptible haplotype in the six members in which there were four patients (I-2,II-2,II-4,III-1). Conclusion Several susceptible locus are involved in PsV in this family . Our research demonstrated the positive association of the haplotype 1-13-7 with the early -onset psoriasis vulgaris.It may be due to increase individual's sensitivity to genetic factors ,as well as , environmental factors. The penetrance of the haplotype susceptible to psoriasis was affected by many factors.