Abstract: Objective To understand the effects of C-reactive protein (CRP) on lectin-like oxidized low density lipoprotein receptor-1 expression on THP-1 derived macrophages and the related signal transduction pathways. Methods THP-1 cells were differentiated into macrophages under the stimulation of PMA. THP-1 derived macrophages were incubated with CRP of various concentration in vitro, co-incubated with inhibitors of NF-κB、AP-1 and MARK signal transduction pathways. The expressions of LOX-1 antigen and mRNA were analyzed by ELISA and RT-PCR, respectively. Result CRP stimulated the expression of LOX-1 antigen and mRNA on macrophages in a dose-dependent manner. NF-κB inhibitor BAY11-7085 suppressed the inducible effects of CRP on LOX-1 expression. Conclusion CRP increased LOX-1 expression on THP-1 derived macrophages at transcription and post-transcription levels. The NF-κB signal transduction pathway may be involved in such process.