Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (5): 837-841.doi: 10.16352/j.issn.1001-6325.2023.05.0837

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Progress on the role of 11β-HSD1 in inflammation,development of hepatocellular carcinoma and immunity

LEI Xingyu1, FENG Xuesong1, CHAO Xu1,2*   

  1. 1. College of Basic Medicine Sciences, Shaanxi University of Chinese Medicine, Xianyang 712046;
    2. The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xi'an 712000, China
  • Received:2022-12-12 Revised:2023-03-21 Online:2023-05-05 Published:2023-04-26
  • Contact: *

Abstract: The 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) with anti-inflammatory or pro-inflammatory effects in inflammatory diseases is related to metabolism, as well as in the immune response through regulatpn of glucocorticoid (GC) synthesis. The expression and functional activity of 11β-HSD1 are potentially induced by pro-inflammatory cytokines, this process relies on the NF-κB signaling pathway and is ultimately determined by the utilization levels of HSD11B1 P1 and P2 promoters. In addition, 11β-HSD1 inhibits the proliferation of hepatocellular carcinoma by reducing glucose intake and glycolysis in hepatocellular carcinoma, and thus plays a role in the development of T cells in thymus and the form of angiogenesis by regulating the level of GC. Understanding the molecular regulatory mechanism of 11β-HSD1 in inflammatory diseases, carcinogenesis, development and immune response is conducive to exploring the occurrence and development of related diseases.

Key words: 11β-hydroxysteroid dehydrogenase 1(11β-HSD1), inflammation, carcinogenesis, immunity

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