Abstract: Objective To explore the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on pregnancy outcome in women of childbearing age. Methods The project was a multi-center investigation covering May 2021 to November 2022 the First People's Hospital of Wuhu, Wuwei City People's Hospital, Nanling Hospital, Wuhu Fanchang District People's Hospital childbirth and abortion. The investigation included 1 987 cases of pregnant and parturient women of childbearing age, with 1 346 cases of SARS-CoV-2 vaccinated, and 641 unvaccinated. Pregnancy outcomes including neonatal weight, 5-minute Apgar score, and neonatal intensive care unit (NICU). Results There were differences between the vaccinated group and the unvaccinated group in age distribution of pregnancy and whether the women were multiparous(P＜0.05,P＜0.001). There was no difference in the fetal live birth rate between the two groups. Excluding pregnancy outcomes abortion and stillbirth, the results showed that there was no differencein delivery outcomes (including neonatal morphology, body weight, NICU and 5-minute Apgar score between the two groups. Conclusions SARS-CoV-2 accination has no negative impact on pregnancy outcome in childbearing women.

Key words: COVID-19, SARS-CoV-2 vaccine, pregnant woman, pregnancy outcome