Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (3): 490-494.doi: 10.16352/j.issn.1001-6325.2023.03.490

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Advances in the study of the correlation between vitamin D-24-hydroxylase and thyroid carcinoma

CHEN Shijing, FU Jinglan, DENG Yuanyuan, ZHANG Ying, LIU Huixia*   

  1. Department of Geriatric Endocrinology, Xiangya Hospital, Central South University, Changsha 410031, China
  • Received:2022-05-09 Revised:2022-11-30 Online:2023-03-05 Published:2023-02-27
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Abstract: Thyroid carcinoma(TC) is the most common malignant tumor of endocrine system. Patients with vitamin D deficiency have an increased risk of TC. Vitamin D-24-hydroxylase (CYP24A1) is main inactivating enzyme of active vitamin D which may inhibit the antiproliferative effect of vitamin D and promote the development of TC by inactivating 1,25-dihydroxyvitamin D3.

Key words: vitamin D-24-hydroxylase, thyroid carcinoma, vitamin D

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