Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (3): 481-485.doi: 10.16352/j.issn.1001-6325.2023.03.481

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Research progress on the role of neutrophil extracellular traps in lung diseases

DING Yu, WU Yan, BIAN Tao*   

  1. Department of Respiratory and Critical Care Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi 214023,China
  • Received:2022-01-10 Revised:2022-05-30 Online:2023-03-05 Published:2023-02-27
  • Contact: *

Abstract: Neutrophils are resident immune cells in the lung, which can release decondensed chromatin containing neutrophil elastases, myeloperoxidases, citrullinated histones and cytoskeletal proteins upon stimulation, namely neutrophil extracellular traps(NETs). NETs play an anti-infective role in lung diseases. But excessive NETs release potentially leads to cause lung tissue injury, enhances inflammatory response and promotes tumor metastasis. These results of research provide some new ideas for the development of potential drugs.

Key words: neutrophil extracellular traps, lung disease

CLC Number: