Research progress on the role of mitochondrial SIRT3 in organ fibrosis

doi:10.16352/j.issn.1001-6325.2022.10.1799

Abstract

Abstract: Organ fibrosis is the main cause of organ dysfunction, and there is no effective anti-fibrosis clinical therapy yet. SIRT3 is an important mitochondrial deacetylase that plays a role in organ fibrosis by regulating mitochondrial protein acetylation level to protect mitochondria from various types of damage. SIRT3 can retard or inhibit the process of organ fibrosis by regulating mitochondrial metabolism, oxidative stress, mitochondrial dynamics, mitochondrial DNA damage, autophagy and apoptosis.

Key words: SIRT3, mitochondrion, deacetylase, fibrosis

CLC Number:

QI Jun-qing, CAO Meng-fei, ZHAO Qian-ru, YIN Jun. Research progress on the role of mitochondrial SIRT3 in organ fibrosis[J]. Basic & Clinical Medicine, 2022, 42(11): 1799-1803.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2022.10.1799

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2022/V42/I11/1799

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