Research progress on the role of mitochondrial SIRT3 in organ fibrosis

doi:10.16352/j.issn.1001-6325.2022.10.1799

Abstract

Abstract: Organ fibrosis is the main cause of organ dysfunction, and there is no effective anti-fibrosis clinical therapy yet. SIRT3 is an important mitochondrial deacetylase that plays a role in organ fibrosis by regulating mitochondrial protein acetylation level to protect mitochondria from various types of damage. SIRT3 can retard or inhibit the process of organ fibrosis by regulating mitochondrial metabolism, oxidative stress, mitochondrial dynamics, mitochondrial DNA damage, autophagy and apoptosis.

Key words: SIRT3, mitochondrion, deacetylase, fibrosis

CLC Number:

QI Jun-qing, CAO Meng-fei, ZHAO Qian-ru, YIN Jun. Research progress on the role of mitochondrial SIRT3 in organ fibrosis[J]. Basic & Clinical Medicine, 2022, 42(11): 1799-1803.

References 25

[1]	Chen X,Hao B,Li D,et al. Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis[J]. Pineal Res,2021,71:e12755.doi: 10.1111/jpi.12755.
[2]	Sun R,Kang X,Zhao Y,et al. Sirtuin 3-mediated deacetylation of acyl-CoA synthetase family member 3 by protocatechuic acid attenuates non-alcoholic fatty liver disease[J].Br J Pharmacol,2020,177:4166-4180.
[3]	Thelen MP,Wirth B,Kye MJ. Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons[J].Acta Neuropathol Commun, 2020, 8: 223. doi: 10.1186/s40478-020-01101-6.
[4]	Sheng X,Cristea IM.The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection[J].PLoS Pathog, 2021, 17: e1009506. doi: 10.1371/journal.ppat.1009506.
[5]	Chen KC, Chen CR, Chen CY,et al. Bicalutamide exhibits potential to damage kidney via destroying complex I and affecting mitochondrial dynamics[J]. Clin Med,2021,11: 135. doi: 10.3390/jcm11010135.
[6]	Zhao W, Sui M, Chen R,et al. SIRT3 protects kidneys from ischemia-reperfusion injury by modulating the DRP1 pathway to induce mitochondrial autophagy[J]. Life Sci,2021,286:120005. doi: 10.1016/j.lfs.2021.120005.
[7]	Peng S,Lu XF,Qi YD,et al. LCZ696 ameliorates oxidative stress and pressure overload-induced pathological cardiac remodeling by regulating the Sirt3/MnSOD path-way[J]. Oxid Med Cell Longev,2020,2020:9815039. doi: 10.1155/2020/9815039.
[8]	Gao J,Wei T,Huang C,et al. Sirtuin 3 governs autophagy-dependent glycolysis during Angiotensin Ⅱ-induced endothelial-to-mesenchymal transition[J]. FASEB J, 2020,34:16645-16661.
[9]	Cheresh P,Kim SJ,Jablonski R,et al. SIRT3 over-expression ameliorates asbestos-induced pulmonary fibrosis, mt-DNA damage, and lung fibrogenic monocyte recruitment[J]. Int J Mol Sci,2021,22:6856. doi: 10.3390/ijms22136856.
[10]	Bindu S,Pillai VB,Kanwal A,et al. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by prevent-ing mitochondrial DNA damage[J]. Am J Physiol Lung Cell Mol Physiol,2017,312:L68-L78.
[11]	程玲莉,杨定平,刘杰,等. SIRT3在小鼠缺血再灌注致急性肾损伤早期纤维化中的作用[J].武汉大学学报(医学版),2019,40:350-355.
[12]	Zhang Y,Wen P,Luo J,et al. Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis[J]. Cell Death Dis,2021,12: 847. doi: 10.1038/s41419-021-04134-4.
[13]	武月玲,曲海霞,王俊星. 右美托咪啶上调sirtuin3减轻小鼠肾缺血-再灌注损伤[J]. 基础医学与临床, 2020, 40: 374-379.
[14]	Dong L,Yu L,Zhong J. Histone lysine-specific demethy-lase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy[J]. Diabetol Metab Syndr,2022,14: 2. doi: 10.1186/s13098-021-00771-z.
[15]	Feng X,Su H,He X,et al. SIRT3 deficiency sensitizes angiotensin-Ⅱ-induced renal fibrosis[J]. Cells,2020,9:2510. doi: 10.3390/cells9112510.
[16]	Lin JR,Zheng YJ,Zhang ZB,et al. Suppression of endothelial-to-mesenchymal transition by SIRT (Sirtuin) 3 alleviated the development of hypertensive renal injury[J]. Hypertension,2018,72:350-360.
[17]	Chen C,Gu J,Wang J,et al. Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression[J]. Int Immunopharmacol,2021,90: 107206. doi:10.1016/j.intimp.2020.107206.
[18]	Li R,Xin T,Li D,et al. Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease:the role of the ERK-CREB pathway and Bnip3-mediated mitophagy[J]. Redox Biol,2018,18:229-243.
[19]	Chelladurai P,Boucherat O,Stenmark K,et al. Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy[J]. Br J Pharmacol,2021,178:54-71.
[20]	Quan Y, Park W, Jin J,et al. Sirtuin 3 Activation by honokiol decreases unilateral ureteral obstruction-induced renal Inflammation and fibrosis via regulation of mitochondrial dynamics and the renal NF-κBTGF-β1/Smad signaling pathway[J]. Int J Mol Sci, 2020,21:402. doi:10.3390/ijms21020402.
[21]	Zhang M,Wang S,Cheng Z,et al. Polydatin ameliorates diabetic cardiomyopathy via Sirt3 activation[J].Biochem Biophys Res Commun,2017,493:1280-1287.
[22]	Zhang M,Lin J,Wang S,et al. Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling[J]. J Pineal Res,2017,63. doi:10.1111/jpi.12418.
[23]	Zhang HX,Li YN,Wang XL,et al. Probucol ameliorates EMT and lung fibrosis through restoration of SIRT3 expression[J]. Pulm Pharmacol Ther,2019,57:101803. doi:10.1016/j.pupt.2019.101803
[24]	Mandala A,Chen WJ,Armstrong A,et al. PPAR agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and -catenin signaling[J]. Am J Physiol Gastrointest Liver Physiol,2021,321:G262-G269.
[25]	Hernandez-Gonzalez F,Faner R,Rojas M,et al. Cellular senescence in lung fibrosis[J]. Int J Mol Sci,2021,22:7912. doi:10.3390/ijms22137012.