Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (10): 1601-1605.doi: 10.16352/j.issn.1001-6325.2022.10.1601

• Mini Reviews • Previous Articles     Next Articles

Research progress of the role of Kisspeptin in puberty onset

ZHAO Zi-jun, MA Wei*   

  1. Department of Medicine,Northwest Minzu University,Lanzhou 730000, China
  • Received:2022-04-24 Revised:2022-07-21 Online:2022-10-05 Published:2022-09-23
  • Contact: *

Abstract: Kisspeptin activates the hypothalamic-pituitary-gonadal axis (HPGA) and regulates the pulsatile secretion of gonadotropin-releasing hormone (GnRH) through KNDy neurons, thereby regulating the initiation of the pubertal phase. This review focuses on the mechanism of GnRH regulation by Kisspeptin and the role of Kisspeptin in the hypothalamic, pituitary and ovarian, aiming to provide reference for clinical management of abnormal pubertal development.

Key words: puberty onset, Kisspeptin, GnRH, hypothalamic pituitary gonadal axis, KNDy neurons

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