Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (5): 809-813.doi: 10.16352/j.issn.1001-6325.2022.05.002

• Mini Reviews • Previous Articles     Next Articles

Research progress on the inflammatory mechanisms of cholestatic liver injury

KANG Jin-yu1, LUO Jia1, GAO Ze-tian1, ZHENG Wen-tao1, LIU Ai-ming1, SONG Yu-fei2*   

  1. 1. School of Medicine, Ningbo University, Ningbo 315211;
    2. the Affiliated Lihuili Hospital, Ningbo University, Ningbo 315211, China
  • Received:2021-02-09 Revised:2021-06-08 Online:2022-05-05 Published:2022-04-28
  • Contact: *

Abstract: Cholestatic liver injury (CLI) is a liver disease with high mordity. Accumulation of bile acids in the liver is thought to be a major driver of liver injury during cholestasis. The disease can develop into be liver fibrosis, cirrhosis, liver failure and liver cancer. This review focuses on the molecular mechanism of CLI in the perspective of inflammatory response. The roles of neutrophils, Kupffer cells, bile duct cells, and the signaling pathways involved in CLI are reviewed to provide clues for research of new therapeutic targets and treatment strategies.

Key words: cholestatasis, liver injury, inflammation, neutrophils, c-Jun N-terminal kinase

CLC Number: