Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (2): 311-315.doi: 10.16352/j.issn.1001-6325.2022.02.018

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Advances in research on blood pressure regulation by clock gene PER

JI Hui-fang, FU Yang, DONG Yi-fei*   

  1. Department of Cardiovascular Medicine,Jiangxi Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330006,China
  • Received:2020-09-17 Revised:2021-01-04 Published:2022-01-24
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Abstract: The abnormal expression of clock genes is closely related to the circadian rhythm of blood pressure and to the occurrence and development of hypertension. This article summarizes the relationship between the clock gene period (PER) and the circadian rhythm of blood pressure, the influence of abnormal expression of PER in peripheral tissues and organs related to blood pressure regulation on blood pressure, and the research progress in the field of hypertension chronotherapy. The author hopes to provide new ideas for the clinical diagnosis, treatment and prognosis of hypertension.

Key words: PER, blood pressure circadian rhythm, hypertension, chronotherapy

CLC Number: