基础医学与临床 ›› 2010, Vol. 30 ›› Issue (5): 554-556.

• 短篇综述 • 上一篇    下一篇

自噬在缺血性心脏病发病机制中的作用

李桂兰 杨洪双 郭彦   

  1. 聊城大学生命科学学院
  • 收稿日期:2009-07-27 修回日期:2009-10-21 出版日期:2010-05-05 发布日期:2010-05-05
  • 通讯作者: 李桂兰

Role of autophagy in the pathogenesis of ischemic heart disease

Gui-lan LI, Hong-shuang YANG, Yan GUO   

  1. School of Life Science,Liaocheng Univercity
  • Received:2009-07-27 Revised:2009-10-21 Online:2010-05-05 Published:2010-05-05
  • Contact: Gui-lan LI,

摘要: 在心肌缺血再灌注过程可以通过多种因素诱导细胞的自噬活动,心肌细胞自噬可以保护细胞,减少细胞损失,但是自噬也可导致心肌细胞死亡。

关键词: 细胞自噬, 缺血/再灌注, 心肌细胞, 缺血性心脏病

Abstract: Autophagy is induced by a diversity of signals during ischemia and reperfusion.Autophagy has been shown to protect cardiac cells and reduce the cell loss, but it also has been shown that enhanced autophagy contributes to cell death during I/R.

Key words: cell autophagy, ischemia/reperfusion, cardiac myocyte, ischemic heart disease