关键词: 血管生成作用, 甘油水通道, 细胞迁移, 细胞增殖, 水通道蛋白

Abstract: The aquaporins (AQPs) are small, integral-membrane proteins that selectively transport water across cell plasma membranes. AQPs are strongly expressed in tumor cells of different origins, particularly aggressive tumors. AQPs-expressing cancer cells show enhanced migration in vitro and greater local tumor invasion, tumor cell extravasations, and metastases in vivo. AQPs inhibition will provide a help for titumor therapy.

Key words: Angiogenesis, Aquaglyceroporin, Cell migration, Cell motility, Cell proliferation, Water channel