基础医学与临床 ›› 2008, Vol. 28 ›› Issue (6): 642-645.
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刘家卓 王建祥
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Jia-zhuo LIU, Jian-xiang WANG
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摘要： P53分子介导的凋亡途径是细胞内重要的信号整合机制，通过识别细胞损伤启动下游促凋亡信号。PIG7是与P53诱导凋亡密切相关的基因，与代谢、炎症、肿瘤等关系紧密，逐渐成为近年相关领域的研究热点。本文从PIG7基因的发现、生物学功能及与人类疾病的关系等方面对该基因的研究进展予以综述。
关键词: P53, PIG7, LITAF, SIMPLE, 基因表达调控, Charcot-Marie-Tooth病, 炎性肠病, 肿瘤
Abstract: Apoptosis induced by P53 gene is one of the most important mechanisms of signal integration in cells，which identify the cell injury and start downstream apoptotic signals. PIG7 gene is induced by P53 and correlates with metabolism, inflammation and tumor. In this review, we mostly described the recent findings in the molecular biology of PIG7 gene and the correlation with human diseases.
Key words: P53, PIG7, LITAF, SIMPLE, Regulation of gene expression, Charcot-Marie-Tooth Disease, IBD, Carcinoma.
刘家卓 王建祥. PIG7基因与疾病[J]. 基础医学与临床, 2008, 28(6): 642-645.
Jia-zhuo LIU; Jian-xiang WANG. PIG7 gene and human diseases[J]. Basic & Clinical Medicine, 2008, 28(6): 642-645.
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