基础医学与临床 ›› 2008, Vol. 28 ›› Issue (6): 638-641.
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肖堃 张烜
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Kun XIAO, Xuan ZHANG
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摘要： 硬皮病是一种以纤维化为主要病变的结缔组织病，其发病机制尚不清楚，临床缺乏有效治疗，迫切需要建立合适的动物模型对之展开研究。本文简述了博来霉素诱导的硬皮病小鼠模型的建立方法，并对其在发病机制和治疗学方面的研究作了归纳。
Abstract: Systemic Sclerosis(SSc) is a fibrotic disease characterized by immunological abnormalities，vascular injury and increased accumulation of extracellular matrix. The etiology has not been fully elucidated yet, so we need to establish a suitable animal model for research. This review is to introduce murine models of bleomycin-induced SSc, and summarize research works on the pathogenesis and treatment of SSc based on this model.
肖堃 张烜. 博来霉素诱导的硬皮病小鼠研究进展[J]. 基础医学与临床, 2008, 28(6): 638-641.
Kun XIAO; Xuan ZHANG. Research update on bleomycin-induced systemic sclerosis[J]. Basic & Clinical Medicine, 2008, 28(6): 638-641.
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