磷酸二酯酶5在心力衰竭中作用的研究进展

doi:10.16352/j.issn.1001-6325.2024.05.0724

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (5): 724-728.doi: 10.16352/j.issn.1001-6325.2024.05.0724

磷酸二酯酶5在心力衰竭中作用的研究进展

杨洋, 张雅茸, 杨红琴, 王婧, 赵红梅^*

中国医学科学院基础医学研究所北京协和医学院基础学院病理生理学系,北京 100005

收稿日期:2024-02-01 修回日期:2024-03-19 出版日期:2024-05-05 发布日期:2024-04-23
通讯作者: ^*hongmeizhao@ibms.pumc.edu.cn
基金资助:
国家自然科学基金(82270403);国家重点研发计划(2019YFA0801804, 2019YFA081703)

Research progress of phosphodiesterase 5 in heart failure

YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei^*

Department of Pathophysiology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005, China

Received:2024-02-01 Revised:2024-03-19 Online:2024-05-05 Published:2024-04-23
Contact: ^*hongmeizhao@ibms.pumc.edu.cn

摘要/Abstract

摘要： 磷酸二酯酶5(PDE5)是环磷酸鸟苷(cGMP)特异性水解酶,是由一氧化氮(NO)激活的可溶性鸟苷酸环化酶(sGC)靶向cGMP产生的。PDE5催化cGMP中磷酸二酯键的水解,从而将cGMP转化为无活性的5′-GMP形式,cGMP-PKG轴功能障碍将引起心脏重塑,是心力衰竭(HF)的主要原因之一。但PDE5抑制剂治疗心力衰竭的临床疗效存在争议。本文总结了近年来PDE5在心力衰竭中的作用机制和研究进展,对未来临床应用PDE5靶向治疗心力衰竭具有重要的指导意义。

关键词: 心力衰竭, 磷酸二酯酶5, 磷酸二酯酶抑制剂, 环磷酸鸟苷

Abstract: Phosphodiesterase 5 (PDE5), a cyclic guanosine monophosphate (cGMP)-specific hydrolase, is targets cGMP produced by soluble guanosine cyclase (sGC) that is activated by nitric oxide (NO). It catalyzes the hydrolysis of the phosphodiester bond in cGMP and converts cGMP to the inactive 5′-GMP form. The cGMP-PKG axis dysfunction is one of the main causes of heart failure (HF) and causes cardiac remodeling. However, the clinical efficacy of PDE5 inhibitors in the treatment of heart failure is controversial. This paper summarizes the mechanism and research progress of PDE5 in heart failure in recent years, which has important significance for the clinical application of PDE5 in heart failure.

Key words: heart failure, phosphodiesterase 5, phosphodiesterase inhibitor, cyclic guanosine monophosphate

中图分类号:

R363

杨洋, 张雅茸, 杨红琴, 王婧, 赵红梅. 磷酸二酯酶5在心力衰竭中作用的研究进展[J]. 基础医学与临床, 2024, 44(5): 724-728.

YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei. Research progress of phosphodiesterase 5 in heart failure[J]. Basic & Clinical Medicine, 2024, 44(5): 724-728.

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磷酸二酯酶5在心力衰竭中作用的研究进展

Research progress of phosphodiesterase 5 in heart failure

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