[1]Song C,Zhou C. HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis[J]. J Exp Clin Cancer Res, 2021, 401: 62.doi: 10.1186/s13046-021-01859-0. [2]You X, Wu J, Zhao X, et al. Fibroblastic galectin-1-fostered invasion and metastasis are mediated by TGF-β1-induced epithelial-mesenchymal transition in gastric cancer[J]. Aging (Albany NY), 2021, 1314: 18464-18481. [3]Zhang X, Zhang P, Shao M, et al. SALL4 activates TGF-β/SMAD signaling pathway to induce EMT and promote gastric cancer metastasis[J]. Cancer Manag Res, 2018, 10: 4459-4470. [4]Liu J, Dai X, Guo X, et al. Circ-OXCT1 suppresses gastric cancer EMT and metastasis by attenuating TGF-β pathway through the Circ-OXCT1/miR-136/SMAD4 axis[J]. Onco Targets Ther, 2020, 13: 3987-3998. [5]Li B, Xia Y, Lv J, et al. miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche[J]. Oncogene, 2021, 4043: 6180-6194. [6]Lu J, Bang H, Kim SM, et al. Lymphatic metastasis-related TBL1XR1 enhances stemness and metastasis in gastric cancer stem-like cells by activating ERK1/2-SOX2 signaling[J]. Oncogene, 2021, 405: 922-936. [7]Kim BK, Cheong JH, Im JY, et al. PI3K/AKT/β-catenin signaling regulates vestigial-like 1 which predicts poor prognosis and enhances malignant phenotype in gastric cancer[J]. Cancers (Basel), 2019, 1112.doi: 10.3390/cancers11121923. [8]Du F, Feng W, Chen S, et al. Sex determining region Y-box 12 (SOX12) promotes gastric cancer metastasis by upregulating MMP7 and IGF1[J]. Cancer Lett, 2019, 452: 103-118. [9]Jiang L, Chen Y, Min G, et al. Bcl2-associated athanogene 4 promotes the invasion and metastasis of gastric cancer cells by activating the PI3K/AKT/NF-κB/ZEB1 axis[J]. Cancer Lett, 2021, 520: 409-421. [10]Xu E, Xia X, Jiang C, et al. GPER1 silencing suppres-ses the proliferation, migration, and invasion of gastric cancer cells by inhibiting PI3K/AKT-mediated EMT[J]. Front Cell Dev Biol, 2020, 8: 591239.doi: 10.3389/fcell.2022.841792. [11]张生军,常琦,刘敏丽. Livin通过Akt信号途径促进胃癌SGC7901细胞的上皮细胞间质转换[J]. 基础医学与临床, 2016, 365: 586-589. [12]Liu W, Gou H, Wang X, et al. TTPAL promotes gastric tumorigenesis by directly targeting NNMT to activate PI3K/AKT signaling[J]. Oncogene, 2021, 4049: 6666-6679. [13]Liang X, Qin C, Yu G, et al. Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway[J]. Mol Ther Oncolytics, 2021, 23: 501-514. [14]Ge Q, Hu Y, He J, et al. Zic1 suppresses gastric cancer metastasis by regulating Wnt/β-catenin signaling and epithelial-mesenchymal transition[J]. Faseb J, 2020, 342: 2161-2172. [15]Tian S, Peng P, Li J, et al. SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway[J]. Aging (Albany NY), 2020, 124: 3574-3593. [16]Chi HC, Tsai CY, Wang CS, et al. DOCK6 promotes chemo-and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits[J]. Oncogene, 2020, 3937: 5933-5949. [17]Peng Y, Xu Y, Zhang X, et al. A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression[J]. Mol Cancer, 2021, 201: 158.doi: 10.1186/s12943-021-01457-w. [18]Yang XZ, Cheng TT, He QJ, et al. LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway[J]. Mol Cancer, 2018, 171: 126.doi: 10.1186/s12943-018-0874-1. [19]Gao Z, Long Y, Wu Y, et al. LncRNA LINC02253 activates KRT18/MAPK/ERK pathway by mediating N6-methyladenosine modification of KRT18 mRNA in gastric cancer[J]. Carcinogenesis, 2022, 435: 419-429. [20]Shi Y,Sun H. Down-regulation of lncRNA LINC00152 suppresses gastric cancer cell migration and invasion through inhibition of the ERK/MAPK signaling pathway[J]. Onco Targets Ther, 2020, 13: 2115-2124. [21]Sun YY, Zhang H, Ma RR, et al. Long non-coding RNA AK025387 promotes cell migration and invasion of gastric cancer[J]. Front Oncol, 2020, 10: 633.doi: 10.3389/fonc.2020.00633. [22]Wang X, Liang Q, Zhang L, et al. C8orf76 promotes gastric tumorigenicity and metastasis by directly inducing lncRNA DUSP5P1 and associates with patient outcomes[J]. Clin Cancer Res, 2019, 2510: 3128-3140. [23]Sun B,Zhong FJ. ELTD1 promotes gastric cancer cell proliferation, invasion and epithelial-mesenchymal transition through MAPK/ERK signaling by regulating CSK[J]. Int J Gen Med, 2021, 14: 4897-4911. [24]Zhang C, Zhao S, Tan Y, et al. The SKA3-DUSP2 axis promotes gastric cancer tumorigenesis and epithelial-mesenchymal transition by activating the MAPK/ERK pathway[J]. Front Pharmacol, 2022, 13: 777612.doi: 10.3389/fphar.2022.777612. [25]Doheny D, Manore SG, Wong GL, et al. Hedgehog signaling and truncated GLI1 in cancer[J]. Cells, 2020, 99.doi: 10.3390/cells9092114. [26]Xu QH, Xiao Y, Li XQ, et al. Resveratrol counteracts hypoxia-induced gastric cancer invasion and EMT through Hedgehog pathway suppression[J]. Anticancer Agents Med Chem, 2020, 209: 1105-1114. [27]Wu L, Wang S, Tang B, et al. Human telomerase reverse transcriptase (hTERT) synergistic with Sp1 upregulate Gli1 expression and increase gastric cancer invasion and metastasis[J]. J Mol Histol, 2021, 526: 1165-1175. [28]Sun DP, Tian YF, Lin CC, et al. A novel mechanism driving poor-prognostic gastric cancer: overexpression of the transcription factor Krüppel-like factor 16 promotes growth and metastasis of gastric cancer through regulating the Notch pathway[J]. Am J Cancer Res, 2021, 116: 2717-2735. [29]Huang B, Jin G, Qu C, et al. Elevated expression of NOTCH1 associates with lymph node metastasis of gastric cancer and knock-down of NOTCH1 attenuates tumor cell progression[J]. Med Sci Monit, 2019, 25: 9939-9948. [30]Liu Z, Li J, Ding Y, et al. USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer[J]. Oncogene, 2022, 4118: 2555-2570. [31]Liu H, Liu N, Zhao Y, et al. Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling[J]. Aging (Albany NY), 2019, 1121: 9643-9660. [32]Gao Y, Li J, Xi H, et al. Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway[J]. Br J Cancer, 2020, 12212: 1837-1847. [33]Zhou W, Xian Q, Wang Q, et al. m6A methyltransferase 3 promotes the proliferation and migration of gastric cancer cells through the m6A modification of YAP1[J]. J Oncol, 2021, 2021: 8875424.doi: 10.1155/2021/8875424. [34]Yao Y, Liu Z, Huang S, et al. The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway[J]. Cell Death Discov, 2022, 81: 79.doi: 10.1038/s41420-022-00868-y. [35]Yang Y, Zhang Q, Liang J, et al. STAM2 knockdown inhibits proliferation, migration, and invasion by affecting the JAK2/STAT3 signaling pathway in gastric cancer[J]. Acta Biochim Biophys Sin (Shanghai), 2021, 536: 697-706. [36]Wei KL, Chou JL, Chen YC, et al. Epigenetic silencing of STAT3-targeted miR-193a, by constitutive activation of JAK/STAT signaling, leads to tumor progression through overexpression of YWHAZ in gastric cancer[J]. Front Oncol, 2021, 11: 575667.doi: 10.3389/fonc.2021.575667. |