抑郁症状增加中国老年人跌倒风险

doi:10.16352/j.issn.1001-6325.2022.06.027

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (6): 945-949.doi: 10.16352/j.issn.1001-6325.2022.06.027

抑郁症状增加中国老年人跌倒风险

刘延丽¹, 赵瑞雪², 潘燕², 马雅军², 赵暾², 蒋晓燕³, 李淑娟^4*

1.北京怀柔医院神经内科,北京 101400;
2.首都医科大学附属北京朝阳医院神经内科,北京 100020;
3.同济大学医学院病理学与病理生理学系心律失常教育部重点实验室,上海 200092;
4.中国医学科学院北京协和医学院国家心血管疾病中心阜外医院神经内科,北京 100034

收稿日期:2022-03-10 修回日期:2022-04-22 出版日期:2022-06-05 发布日期:2022-06-02
通讯作者: * lishujuan@fuwai.com
基金资助:
国家重点研发计划(2018YFC2000400,2018YEC2002000);国家自然科学基金(81971102)

Depressive symptoms increase the risk of falls in elderly Chinese

LIU Yan-li¹, ZHAO Rui-xue², PAN Yan², MA Ya-jun², ZHAO Tun², JIANG Xiao-yan³, LI Shu-juan^4*

1. Department of Neurology, Beijing Huairou District Hospital, Beijing 101400;
2. Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020;
3. Key Laboratory of Arrhythmias, Ministry of Education, Department of Pathology, School of Medicine, Tongji University, Shanghai 200092;
4. Department of Neurology, Fuwai Hospital, National Center for Cardiovascular Diseases, CAMS & PUMC, Beijing 100034, China

Received:2022-03-10 Revised:2022-04-22 Online:2022-06-05 Published:2022-06-02
Contact: * lishujuan@fuwai.com

摘要/Abstract

摘要： 目的探讨抑郁症状是否为中国老年人跌倒的潜在危险因素。方法数据取自如皋长寿和衰老研究的子队列,通过简版老年抑郁量表(GDS-15)评估老年人抑郁情况,收集并记录研究对象于2014年基线及2017年随访时的跌倒发生情况。根据抑郁情况,将研究对象分为抑郁组和非抑郁组,比较组间一般资料及跌倒发生情况;应用Logistic回归分析抑郁症状是否增加老年人跌倒风险。结果横断面研究纳入1 548例研究对象,跌倒的发生率为8.3%。“跌倒”组研究对象年龄较大、受教育程度较低以及认知障碍者所占比重更高;与非抑郁组相比,抑郁组女性、务农、受教育程度较低、非在婚、不吸烟、不饮酒以及认知障碍者所占比例更高;在调整混杂因素后,抑郁症状与老年人基线及3年后跌倒发生风险增高均相关(P＜0.05)。结论在中国社区老年人群中,抑郁症状是跌倒的潜在危险因素。

关键词: 抑郁, 跌倒, 老年人, 队列研究

Abstract: Objective To investigate whether depression is a potential risk factor for falls in the elderly in China. Methods Data were collected from the Subcohort of Rugao Longevity and Aging Study. Depression in the elderly was assessed by the GDS-15(Geriatric Depression Scale), and the occurrence of falls in the subjects at baseline in 2014 and the second follow-up in 2017 were collected and recorded. According to the depression status, subjects were divided into depression group and normal group, and the general information and occurrence of falls were compared between the two groups. Logistic regression was used to analyze whether depression increased the risk of falls in older adults. Results In the cross-sectional study of 1 548 subjects, the incidence of falls was 8.3%. The proportion of subjects in the “fall” group was higher in older age, lower education level and cognitive impairment. Compared with the normal group, the depressed group had a higher proportion of women, farmers, less education, unmarried, non-smokers, non-drinkers and cognitively disabled people. After adjusting for confounders, depression was associated with an increased risk of falls at baseline and 3 years later in older adults (P＜ 0.05). Conclusions Depression is a potential risk factor for falls among the elderly in the Chinese community.

Key words: depression symptoms, falls, elderly, cohort study

中图分类号:

R741

刘延丽, 赵瑞雪, 潘燕, 马雅军, 赵暾, 蒋晓燕, 李淑娟. 抑郁症状增加中国老年人跌倒风险[J]. 基础医学与临床, 2022, 42(6): 945-949.

LIU Yan-li, ZHAO Rui-xue, PAN Yan, MA Ya-jun, ZHAO Tun, JIANG Xiao-yan, LI Shu-juan. Depressive symptoms increase the risk of falls in elderly Chinese[J]. Basic & Clinical Medicine, 2022, 42(6): 945-949.

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抑郁症状增加中国老年人跌倒风险

Depressive symptoms increase the risk of falls in elderly Chinese

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