肠-肾轴在新月体肾炎发病机制中的研究进展

doi:10.16352/j.issn.1001-6325.2022.04.016

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (4): 656-660.doi: 10.16352/j.issn.1001-6325.2022.04.016

肠-肾轴在新月体肾炎发病机制中的研究进展

尹欢欢, 施潇潇, 陈丽萌^*

中国医学科学院北京协和医学院北京协和医院肾内科, 北京 100730

收稿日期:2020-05-21 修回日期:2021-01-24 出版日期:2022-04-05 发布日期:2022-04-01
通讯作者: * chenlimeng@pumch.cn
基金资助:
国家自然科学基金(81970607);中国医学科学院医学与健康科技创新工程项目(CIFMS 2020-I2M-C&T-A-001);北京协和医学院2020年度校级本科教育教学改革立项项目(2020zlgc0101)

Progress of gut-kidney axis in the pathogenesis of crescentic glomerulonephritis

YIN Huan-huan, SHI Xiao-xiao, CHEN Li-meng^*

Department of Nephrology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China

Received:2020-05-21 Revised:2021-01-24 Online:2022-04-05 Published:2022-04-01
Contact: * chenlimeng@pumch.cn

摘要/Abstract

摘要： 新月体肾炎(CreGN)是最凶险的肾小球肾炎,常常导致终末期肾病。免疫机制是其发病和决定预后最重要的因素。近年来,肠道和肠道菌群在包括CreGN在内的多种肾脏病中作用受到关注,其中“肠-肾轴”通过肠道菌群、肠源性免疫细胞等途径会直接影响全身和肾脏免疫应答及相关病理生理机制。

关键词: 肠-肾轴, 肠道菌群, 新月体肾炎, 肠黏膜免疫, 分子模拟

Abstract: Crescent glomerulonephritis (CreGN) is the most dangerous glomerulonephritis and always leads to end stage renal disease (ESRD). The immunological mechanism plays an important role in its pathogenesis and prognosis. Recently, the role of the gut and intestinal microbiota in a variety of kidney diseases including CreGN has been disclosed. The “gut-kidney axis” will directly affect the immune response in the kidney and subsequent pathophysiology through the intestinal microbiota and gut-derived immune cells.

Key words: gut-kidney axis, intestinal microbiota, crescentic glomerulonephritis, intestinal mucosal immunity, molecular simulation

中图分类号:

尹欢欢, 施潇潇, 陈丽萌. 肠-肾轴在新月体肾炎发病机制中的研究进展[J]. 基础医学与临床, 2022, 42(4): 656-660.

YIN Huan-huan, SHI Xiao-xiao, CHEN Li-meng. Progress of gut-kidney axis in the pathogenesis of crescentic glomerulonephritis[J]. Basic & Clinical Medicine, 2022, 42(4): 656-660.

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肠-肾轴在新月体肾炎发病机制中的研究进展

Progress of gut-kidney axis in the pathogenesis of crescentic glomerulonephritis

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