抗视网膜脉络膜新生血管性疾病治疗药物靶点的研究进展

doi:10.16352/j.issn.1001-6325.2022.02.011

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (2): 325-329.doi: 10.16352/j.issn.1001-6325.2022.02.011

抗视网膜脉络膜新生血管性疾病治疗药物靶点的研究进展

刘辰¹, 方思尹¹, 顾操¹, 吴晋晖^2*

1.海军军医大学第一附属医院眼科, 上海 200433;
2.海军军医大学第三附属医院眼科,上海 200438

收稿日期:2021-03-29 修回日期:2021-08-13 发布日期:2022-01-24
通讯作者: ^* wjh2042@aliyun.com
基金资助:
上海市浦江人才项目(17PJD041);海军军医大学,未来战争医学防护技术研发专项(19WLMS-03);上海市中医药管理局(ZHYY-ZXYJHZX-202024)

Research progress on drug targets for anti-retinal and choroidal neovascular diseases

LIU Chen¹, FANG Si-yin¹, GU Cao¹, WU Jin-hui^2*

1. Department of Ophthalmology, the First Affiliated Hospital, Navy Military Medical University, Shanghai 200433;
2. Department of Ophthalmology, the Third Affiliated Hospital, Navy Military Medical University,Shanghai 200438, China

Received:2021-03-29 Revised:2021-08-13 Published:2022-01-24
Contact: ^* wjh2042@aliyun.com

摘要/Abstract

摘要： 新生血管性年龄相关性黄斑变性(nAMD)、糖尿病视网膜病变(DR)等眼底病继发形成新生血管,是致盲的重要原因之一。抗血管内皮生长因子(VEGF)治疗是当前主流疗法。但仍存在部分患者对其疗效欠佳等局限,临床仍需要开发新的药物靶点。

关键词: 视网膜, 脉络膜, 新生血管, 药物靶点

Abstract: The appearance of new blood vessels in the neovascular age-related macular degeneration (nAMD), diabetic retinopathy (DR),and other ocular diseases is one of the important reasons for blindness. Anti-vascular endothelial growth factor (VEGF) drugs are the current mainstream. However, some patients have poor efficacy and other adverse reactions. There is still a need to develop new drugs.

Key words: retina, choroid, revascularization, drug targets

中图分类号:

R774.1

刘辰, 方思尹, 顾操, 吴晋晖. 抗视网膜脉络膜新生血管性疾病治疗药物靶点的研究进展[J]. 基础医学与临床, 2022, 42(2): 325-329.

LIU Chen, FANG Si-yin, GU Cao, WU Jin-hui. Research progress on drug targets for anti-retinal and choroidal neovascular diseases[J]. Basic & Clinical Medicine, 2022, 42(2): 325-329.

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抗视网膜脉络膜新生血管性疾病治疗药物靶点的研究进展

Research progress on drug targets for anti-retinal and choroidal neovascular diseases

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