肾结石患者低柠檬酸尿症代谢相关危险因素分析

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (8): 1177-1180.

肾结石患者低柠檬酸尿症代谢相关危险因素分析

乔逸¹, 肖河^1*, 樊晓红², 石冰冰¹, 纪志刚¹

中国医学科学院北京协和医学院北京协和医院 1.泌尿外科; 2.肾内科, 北京 100730

收稿日期:2021-03-08 修回日期:2021-06-08 出版日期:2021-08-05 发布日期:2021-07-21
通讯作者: *pumchxiaohe@sina.cn

Analysis of metabolism associated risk factors of hypocitrateuria in patients with kidney stone

QIAO Yi¹, XIAO He^1*, FAN Xiao-hong², SHI Bing-bing¹, JI Zhi-gang¹

1. Department of Urology;2.Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100730, China

Received:2021-03-08 Revised:2021-06-08 Online:2021-08-05 Published:2021-07-21
Contact: *pumchxiaohe@sina.cn

摘要/Abstract

摘要： 目的回顾性分析肾结石患者中低柠檬酸尿症的代谢相关危险因素。方法回顾性分析北京协和医院泌尿外科代谢评估数据库中2016年5月至2021年1月纳入的92例临床资料完整的肾结石患者情况,以低柠檬酸尿症为因变量,以性别、年龄和代谢异常因素,包括体质量指数、高血压、糖尿病、高脂血症及高尿酸血症为自变量,通过二元Logistic回归分析,评估低柠檬酸尿症的代谢相关危险因素。结果在肾结石患者中,高血压是低柠檬酸尿症的危险因素(OR=4.48,95% CI:1.58～12.70,P＜0.01),其他各因素并未发现与低柠檬酸尿症明确相关。结论在肾结石患者中,高血压是低柠檬酸尿症的危险因素。

关键词: 肾结石, 低柠檬酸尿症, 代谢相关危险因素

Abstract: Objective To retrospectively analyze metabolism associated risk factors of hypocitrateuria in kidney stone patients. Methods Totally 92 kidney stone patients with qualified data from metabolic evaluation database of Peking Union Medical College Hospital from May 2020 to January 2021 were included in this retrospective analysis . With hypocitrateuria as dependent variable, and gender, age and metabolic factors, including body mass index, hypertension, diabetes mellitus, hyperlipidemia and hyperuricemia, as independent variables,binary Logistic regression was used to analyze metabolism associated risk factors of hypocitraturia. Results In kidney stone patients, hypertension was risk factors of hypocitrateuria (OR=4.48,95% CI:1.58～12.70,P＜0.05), and other factors were not found to be associated with hypocitrateuria. Conclusions In kidney stone patients, hypertension is a risk factor of hypocitrateuria.

Key words: kidney stone, hypocitrateuria, metabolism associated risk factors

中图分类号:

R691.4

乔逸, 肖河, 樊晓红, 石冰冰, 纪志刚. 肾结石患者低柠檬酸尿症代谢相关危险因素分析[J]. 基础医学与临床, 2021, 41(8): 1177-1180.

QIAO Yi, XIAO He, FAN Xiao-hong, SHI Bing-bing, JI Zhi-gang. Analysis of metabolism associated risk factors of hypocitrateuria in patients with kidney stone[J]. Basic & Clinical Medicine, 2021, 41(8): 1177-1180.

参考文献

[1]叶章群,邓耀良. 泌尿系结石诊断治疗指南[M]//黄健,王建业,孔垂泽,等. 中国泌尿外科和男科疾病诊断治疗指南(2019版). 北京: 科学出版社, 2020: 237-267.
[2]Sasaki Y, Kohjimoto Y, Iba A, et al. Weight loss intervention reduces the risk of kidney stone formation in a rat model of metabolic syndrome[J]. Int J Urol, 2015, 22: 404-409.
[3]Tae BS, Balpukov U, Cho SY, et al. Eleven-year cumulative incidence and estimated lifetime prevalence of urolithiasis in Korea: a national health insurance service-national sample cohort based study[J]. J Korean Med Sci, 2018, 33: e13. doi: 10.3346/jkms.2018.33.e13.
[4]Nerli R, Jali M, Guntaka AK, et al. Type 2 diabetes mellitus and renal stones[J]. Adv Biomed Res, 2015, 4: 180-184.
[5]Chu FY, Chang CC, Huang PH, et al. The association of uric acid calculi with obesity, prediabetes, type 2 diabetes mellitus, and hypertension[J]. Biomed Res Int, 2017, 2017: 7523960.doi:10.1155/2017/7523960.
[6]Cohen AJ, Adamsky MA, Nottingham CU, et al. Impact of statin intake on kidney stone formation[J]. Urology, 2019, 124: 57-61.
[7]Masterson JH, Woo JR, Chang DC, et al. Dyslipidemia is associated with an increased risk of nephrolithiasis[J]. Urolithiasis, 2015, 43: 49-53.
[8]Kohjimoto Y, Sasaki Y, Iguchi M, et al. Association of metabolic syndrome traits and severity of kidney stones: results from a nationwide survey on urolithiasis in Japan[J]. Am J Kidney Dis, 2013, 61: 923-929.
[9]Carbone A, Al Salhi Y, Tasca A, et al. Obesity and kidney stone disease: a systematic review[J]. Minerva Urol Nefrol, 2018, 70: 393-400.
[10]Eisner BH, Porten SP, Bechis SK, et al. Diabetic kidney stone formers excrete more oxalate and have lower urine pH than nondiabetic stone form ers[J]. J Urol, 2010, 183: 2244-2248.
[11]Taylor EN, Mount DB, Forman JP, et al. Association of prevalent hypertension with 24-hour urinary excretion of calcium, citrate, and other factors[J]. Am J Kidney Dis, 2006, 47: 780-789.
[12]Rams K, Philipraj SJ, Purwar R, et al. Correlation of metabolic syndrome and urolithiasis: a prospective cross-sectional study[J]. Urol Ann, 2020, 12: 144-149.