血液高凝状态在肝硬化中作用的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (3): 423-427.

血液高凝状态在肝硬化中作用的研究进展

戚婉蓉¹, 毛小荣^2*, 李俊峰²

兰州大学 1.第一临床医学院;2.第一医院感染科,甘肃兰州 730000

收稿日期:2020-03-31 修回日期:2020-06-30 出版日期:2021-03-05 发布日期:2021-03-01
通讯作者: ^*mxr2013@126.com
基金资助:
国家自然科学基金(81800528);甘肃省卫生行业科研计划项目(GSWSKY2018-24);兰州大学第一医院院内基金(ldyyyn2017-17);兰州市城关区科研专项(2018SHFZ0023);甘肃省高等学校科学研究项目(2018B-009)

Research progress of blood hypercoagulable state in liver cirrhosis

QI Wan-rong¹, MAO Xiao-rong^2*, LI Jun-feng²

1. the First Clinical Medical College; 2. Department of Infection, the First Hospital,Lanzhou University, Lanzhou 730000, China

Received:2020-03-31 Revised:2020-06-30 Online:2021-03-05 Published:2021-03-01
Contact: ^*mxr2013@126.com

摘要/Abstract

摘要： 肝硬化患者容易合并凝血功能障碍,血液高凝状态是其中一种表现。血液高凝状态除了参与静脉血栓形成外,最新证据证实其还参与肝损伤、肝再生、肝纤维化的发生。本文从血液高凝状态在肝硬化中的发生机制、肠道微生态环境在其中的作用以及血液高凝状态在肝硬化中最新影响机制的研究进行综述,为肝硬化患者的诊疗提供新理念。

关键词: 血液高凝状态, 肝纤维化, 肝脏再生, 肝损伤, 肠道微生态环境

Abstract: The patients with liver cirrhosis are often complicated with coagulation dysfunction, and blood hypercoagulable state is one of the manifestations. Blood hypercoagulable state is not only involved in thrombosis, the latest evidence confirms that it is also involved in liver injury, liver regeneration and liver fibrosis. This review attempts to discuss the mechanism of blood hypercoagulable state in liver cirrhosis, the role of intestinal microecological environment in it and the latest influence mechanism of blood hypercoagulable state in liver cirrhosis.To provide a new concept for the diagnosis and treatment of patients with liver cirrhosis.

Key words: blood hypercoagulable state, liver fibrosis, liver regeneration, liver injury, intestinal microecological environment

中图分类号:

R512.6

戚婉蓉, 毛小荣, 李俊峰. 血液高凝状态在肝硬化中作用的研究进展[J]. 基础医学与临床, 2021, 41(3): 423-427.

QI Wan-rong, MAO Xiao-rong, LI Jun-feng. Research progress of blood hypercoagulable state in liver cirrhosis[J]. Basic & Clinical Medicine, 2021, 41(3): 423-427.

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