外泌体microRNAs与阿尔茨海默病关系的研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (11): 1542-1545.

外泌体microRNAs与阿尔茨海默病关系的研究进展

刁华琼¹, 李小黎^2*, 林亮吟¹, 刘海鹏¹, 陈弘婧¹, 丁海月¹, 魏丹¹

1.北京中医药大学, 北京 100029;
2.北京中医药大学第三附属医院脑病科,北京 100029

收稿日期:2019-10-18 修回日期:2020-01-03 出版日期:2020-11-05 发布日期:2020-10-30
通讯作者: ^* tigerlxl2002@163.com
基金资助:
国家自然科学基金(81673930)

Progress on the correlation between exosomal microRNAs and Alzheimer's disease

DIAO Hua-qiong¹, LI Xiao-li^2*, LIN Liang-yin¹, LIU Hai-peng¹, CHEN Hong-jing¹, DING Hai-yue¹, WEI Dan¹

1. Beijing University of Chinese Medicine, Beijing 100029;
2. Department of Encephalopath, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China

Received:2019-10-18 Revised:2020-01-03 Online:2020-11-05 Published:2020-10-30
Contact: ^* tigerlxl2002@163.com

摘要/Abstract

摘要： 阿尔茨海默病(AD)是老年期最常见的痴呆类型,具有起病隐匿、进行性发展的特点。外泌体微RNAs(miRNAs)可调节淀粉样前体蛋白的剪切、β淀粉样蛋白(Aβ)沉积及Tau蛋白磷酸化,影响神经炎性斑(NP)和神经原纤维缠结(NFT)的形成。此外,特定miRNAs经外泌体运输能穿过血脑屏障(BBB),抑制Tau蛋白磷酸化。检测外周血中外泌体miRNAs的表达谱有望成为诊疗AD的非侵入性方法。

关键词: 阿尔茨海默病, 外泌体, 微RNAs, β-淀粉样蛋白, Tau蛋白

Abstract: Alzheimer's disease is the most common dementia in the aged population and is characterizd by hidden attack and progressive development. Some studies showed that exosomal microRNAs(miRNAs) regulates the shearing of amyloid precusor protein,deposition of beta-amyloid peptides(Aβ) and phosphorylation of Tau protein, influencing the generation of neuritic plaques and neurofibrillary tangles. In addition, special miRNAs can be transpor-ted by exsome across blood-brain-barrier and inhibit Tau phosphorylation. Measuring the expression profile of exosomal miRNAs in the peripheral blood may be a non-invasive diagnosis and treatment method of AD.

Key words: Alzheimer's disease, exosome, microRNAs, beta-amyloid peptide, Tau protein

中图分类号:

R592

刁华琼, 李小黎, 林亮吟, 刘海鹏, 陈弘婧, 丁海月, 魏丹. 外泌体microRNAs与阿尔茨海默病关系的研究进展[J]. 基础医学与临床, 2020, 40(11): 1542-1545.

DIAO Hua-qiong, LI Xiao-li, LIN Liang-yin, LIU Hai-peng, CHEN Hong-jing, DING Hai-yue, WEI Dan. Progress on the correlation between exosomal microRNAs and Alzheimer's disease[J]. Basic & Clinical Medicine, 2020, 40(11): 1542-1545.

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