基础医学与临床 ›› 2018, Vol. 38 ›› Issue (4): 578-582.
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熊伟鹏
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Weipeng Xiong
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摘要： 肿瘤免疫疗法研究在肿瘤治疗领域取得了突破性的进展。程序性死亡受体1（PD-1）主要表达于T淋巴细胞表面，是一种重要的免疫调节蛋白。PD-1及其配体PD-L1相互作用参与肿瘤诱导的免疫抑制效应。针对PD-1/PD-L1信号通路的抗体药物在临床应用中呈现出显著性的疗效。
关键词: 肿瘤，免疫疗法，程序性死亡受体1，抗体药物
Abstract: Research in immunotherapy has achieved important progress in tumor treatments. Programmed cell death receptor 1 (PD-1) is mainly expressed on the T lymphocyte surface and serves as an important immune regulator. The interactions of PD-1 and its ligand, PD-L1, involve in tumor-induced immunosuppression. Some of the approved antibody drugs targeting PD-1/PD-L1 signaling showed significant clinical benefits.
Key words: tumor, immunotherapy, programmed cell death receptor 1, antibody drug
熊伟鹏. 细胞程序性死亡受体1信号通路在肿瘤免疫疗法中的应用[J]. 基础医学与临床, 2018, 38(4): 578-582.
Weipeng Xiong. Role of programmed cell death receptor 1 signaling pathway in cancer immunotherapy[J]. Basic & Clinical Medicine, 2018, 38(4): 578-582.
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