基础医学与临床 ›› 2017, Vol. 37 ›› Issue (6): 870-873.
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邓资翔,左中
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摘要： ATP结合盒转运蛋白A1(ABCA1)是一种以ATP为能源进行物质转运的膜蛋白，肝脏X受体(LXRs)、维甲酸X受体(RXRs)、固醇调节元结合蛋白(SREBPs)和microRNAs等因子对其表达有重要影响。ABCA1作用于脂质沉积的多个信号通路，上调其表达可负向调控脂质沉积过程，为代谢性疾病带来了新的治疗方向。
关键词: ABCA1, 脂质, microRNAs
Abstract: ATP-binding cassette transporter A1 (ABCA1) is an membrane protein,using ATP for transferring substances,modulated by liver X receptors(LXRs), retinoic X receptors(RXRs), sterol regulatory element binding proteins(SREBPs), microRNAs and other upstream modulators. ABCA1 plays an important role in multiple pathways related to lipid accumulation. Upregulating ABCA1 expression can reduce lipid accumulation, hence offers a promising strategy for metabolic diseases.
Key words: ABCA1, lipids, microRNAs
中图分类号:
R589.2
邓资翔 左中. ABCA1在脂质沉积中的研究进展[J]. 基础医学与临床, 2017, 37(6): 870-873.
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