基础医学与临床 ›› 2016, Vol. 36 ›› Issue (9): 1301-1305.
• 短篇综述 • 上一篇 下一篇
赵倩1,王小平2
收稿日期:
修回日期:
出版日期:
发布日期:
通讯作者:
基金资助:
Received:
Revised:
Online:
Published:
摘要： 热休克蛋白70（HSP70）广泛存在于细胞中，在应激刺激后过表达，可以参与蛋白质的合成及受损蛋白的修复。HSP70在肝癌治疗中的作用日益受到重视：利用其特异性和免疫原性，靶向治疗肝癌。并且可以利用其“分子伴侣”的特点，作为肝癌疫苗，诱发机体抗肝癌的免疫反应。HSP70在肝癌治疗中已初显成效，但也存在很多问题，需要更加深入的研究。总之，HSP70在肝癌治疗中有很大的应用前景。
关键词: 热休克蛋白70, 肝癌
Abstract: Heat shock protein 70(HSP70)exists in cells widely, and is highly expressed in responsing to stress,it also plays an important role in composing and repairing the protein. The function of HSP70 in hepatocellular immunotherapy is becoming more and more important:Because of the specificity, immunogenicity and being molecular chaperone, HSP70can induces the immune responses. But it also has many questions which are needed to research for. In a word,HSP70 has a good prospect in the therapy of hepatocellular carcinoma.
Key words: Heat shock protein70, Hepatocellular carcinoma
赵倩 王小平. 热休克蛋白70与肝癌[J]. 基础医学与临床, 2016, 36(9): 1301-1305.
0 / / 推荐
导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks
链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2016/V36/I9/1301
