基础医学与临床 ›› 2016, Vol. 36 ›› Issue (4): 547-551.
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李冲,王志平
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摘要: 溶瘤腺病毒是一类经过基因工程改造,能够选择性地在肿瘤细胞中复制并溶解、杀伤肿瘤细胞的腺病毒,但不影响正常细胞功能。至今,已尝试多种方式提高溶瘤腺病毒的抗肿瘤活性和安全性,包括改变腺病毒转导方式,利用特异性启动子和增强子驱动治疗基因的表达以及协同放化疗、免疫治疗等。
关键词: 溶瘤腺病毒, 靶向治疗, 肿瘤
Abstract: Oncolytic adenovirus is a category of adenovirus which is reconstructed by genetic engineering. The adenovirus can infect and replicate in a selective and specifical manner until the tumor cell is destroyed, while it is harmless to normal cells during the process. A bulk of strategies, hitherto, have been attempted for improving the antitumor activity and safety of oncolytic adenovirus in treatment of cancer, including altering the way of transduction, utilizing tumor-specific promoter and enhancer control of the expression of therapeutic gene as well as combining with the radiotherapy, chemotherapy or immunotherapy for synergistic effect.
Key words: oncolytic adenovirus, target therapy, cancer
李冲 王志平. 溶瘤腺病毒抗肿瘤策略研究进展[J]. 基础医学与临床, 2016, 36(4): 547-551.
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