基础医学与临床 ›› 2015, Vol. 35 ›› Issue (12): 1677-1681.
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张璐,韩薇
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摘要： Sestrins由应激诱导产生，是在进化上相对保守的蛋白家族，能抑制氧化应激、调节腺苷酸活化蛋白激酶（AMPK）-哺乳动物雷帕霉素作用靶点（mTOR）通路来保护细胞和器官免受应激、老化带来的生理损伤。低氧、缺乏ATP可诱导Sesn2的表达。Sestrin在血糖稳态调节方面意义重大。Sestrins也参与延缓衰老、抑制年龄相关性疾病。
关键词: Sestrins, 氧化应激, 代谢疾病, 衰老
Abstract: Sestrins constitue the protein family which are evolutionarily consvered and stress inducible,they suppress the oxidative stress and regulate adenosine monophosphate-dependent protein kinase (AMPK)- mammalian target of rapamycin (mTOR) signaling and protect cells and organisms from stress and age-related physiological abnormalities.Hypoxia and ATP deficiency induce Sesn2 expression.Sestrins regulation of blood sugar homeostasis is physiologically impotant.Sestrins also contribute to the attenuation of aging and suppression of age-associated diseases.
Key words: Sestrins, Oxidative stress, Metabolic disease, Aging
张璐 韩薇. Sestrins的表达调控及其在代谢疾病、衰老研究中的进展[J]. 基础医学与临床, 2015, 35(12): 1677-1681.
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