基础医学与临床 ›› 2015, Vol. 35 ›› Issue (9): 1267-1270.
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高增法1,吴永娜2,3,李汛2
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摘要： SWI/SNF是一种ATP依赖的染色质重塑复合物，ARID1A基因是SWI/SNF复合物的一个重要亚基，其功能失调可造成染色质重塑异常进而引起肿瘤等疾病的发生。ARID1A在卵巢癌、肝癌、乳腺癌、肾癌和膀胱癌等多种恶性肿瘤中频繁发生低表达或者缺失性突变，表明ARID1A是一种重要的肿瘤抑制基因。
关键词: ARID1A, 染色质重塑, 肿瘤抑制基因, 恶性肿瘤
Abstract: SWI/SNF is an ATP-dependent chromatin remodeling complexes. ARID1A gene is an important subunit of SWI/SNF complexes and its dysfunction can cause abnormal chromatin remodeling resulting in tumorigenesis. ARID1A occurs frequently low expression or deletion mutation in a variety of malignant tumors, such as ovarian cancer, liver cancer, breast cancer, stomach cancer, lung cancer and so on which indicates ARID1A is an important tumor suppressor gene.
Key words: ARID1A, chromatin remodeling, tumor suppressor gene, malignant tumor
中图分类号:
R730.5
高增法 吴永娜 李汛. ARID1A在恶性肿瘤中的研究进展[J]. 基础医学与临床, 2015, 35(9): 1267-1270.
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