基础医学与临床 ›› 2015, Vol. 35 ›› Issue (8): 1134-1138.

• 短篇综述 • 上一篇    下一篇

多重连接探针扩增技术在肿瘤相关基因缺失/重复检测中的应用进展

孙平风,傅芬   

  1. 江西省南昌大学第二附属医院
  • 收稿日期:2015-01-06 修回日期:2015-03-23 出版日期:2015-08-05 发布日期:2015-07-15
  • 通讯作者: 傅芬 E-mail:fu-fen@163.com

Advances of multiplex ligation-dependent probe amplification technology on detection of gene deletions/duplications

1,   

  • Received:2015-01-06 Revised:2015-03-23 Online:2015-08-05 Published:2015-07-15

摘要: 多重连接探针扩增(MLPA)技术应用于检测肿瘤相关基因大片段缺失/重复,不仅有助于了解潜在的肿瘤发展分子机制,而且为肿瘤的诊断和预后提供重要信息,成为肿瘤学研究的主要方向。

关键词: MLPA, 肿瘤相关基因, 缺失/重复, 检测

Abstract: The multiplex ligation-dependent probe amplification (MLPA) technology used in detection of gene deletions/duplications not only helps in understanding the molecular mechanisms underlying the development of cancer, but also provides important information for disease diagnosis and prognosis. Currently, MLPA becomes a hotspot to be applied in testing tumor related gene deletions/duplications mutations.

Key words: MLPA, Tumor related gene, Deletions/duplications, Detection

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