基础医学与临床 ›› 2015, Vol. 35 ›› Issue (2): 240-243.
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王萌,纪汶君,陈莉娜
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摘要： 糖尿病性认知功能障碍是糖尿病的重要并发症之一。胰岛素通过MAPK和PI3-K/Akt信号通路对认知功能具有重要保护作用。胰岛素抵抗可导致tau蛋白的过度磷酸化，形成神经纤维结；可竞争性抑制胰岛素降解酶，减少β淀粉样蛋白的降解；增强氧化应激，破坏神经元结构和功能的完整性，从而损伤认知功能。
关键词: 2型糖尿病, 阿尔兹海默病, 胰岛素抵抗, 认知功能障碍
Abstract: Diabetic cognitive dysfunction is one of the important complications of diabetes mellitus. Insulin plays an important protective role in cognitive function through MAPK and PI3-K/Akt signaling pathway. Insulin resistance may give rise to excessive tau protein phosphorylation, formation of neurofibrillary tangles; competitively inhibit insulin degrading enzyme, reduce the degradation of amyloid β; enhance oxidative stress, further damage the integrity of the neuronal structure and function, eventually lead to cognitive dysfunction.
Key words: type 2 diabetes mellitus, Alzheimer’s disease, insulin resistance, cognitive dysfunction
中图分类号:
R589
王萌 纪汶君 陈莉娜. 糖尿病性认知功能障碍研究进展[J]. 基础医学与临床, 2015, 35(2): 240-243.
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