基础医学与临床 ›› 2013, Vol. 33 ›› Issue (3): 378-381.
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章杰1,2,芦立轩1,江华1
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摘要: 20世纪80年代,美国学者Peter Agre发现质膜上存在一类介导水快速跨膜转运的膜蛋白,这类膜蛋白被称作水通道蛋白。已有大量研究发现胶质细胞表达的水通道蛋白对神经系统疾病的发生有重要作用。本文综述水通道蛋白在胶质细胞的表达定位及其意义,为中枢和周围神经系统疾病的诊断和治疗提供新的靶点。
关键词: 水通道蛋白, 胶质细胞, 神经系统
Abstract: In the 1980s Peter Agre found water channel proteins on plasma membranes, and these proteins were named aquaporins (AQPs ). Several evidences have revealed that expression of AQPs in glial cells contributes a lot to neurological diseases. The purpose of this review is to summarize the localization and significance of AQPs expression in glial cells and to provide new targets for diagnosis and treatment of central and peripheral nervous diseases.
Key words: aquaporins, glial cells, nervous system
中图分类号:
320.2755
章杰 芦立轩 江华. 水通道蛋白在胶质细胞的表达及其意义[J]. 基础医学与临床, 2013, 33(3): 378-381.
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