基础医学与临床 ›› 2012, Vol. 32 ›› Issue (8): 979-982.

• 短篇综述 • 上一篇    下一篇

Fascin蛋白在妇科肿瘤中的研究进展

宋易1,马艺珲2,金平3,黎卫平2   

  1. 1. 兰州大学第一临床医学院
    2. 兰州大学基础医学院病理研究所
    3. 深圳市妇幼保健院
  • 收稿日期:2011-08-23 修回日期:2011-12-02 出版日期:2012-08-05 发布日期:2012-07-17
  • 通讯作者: 黎卫平 E-mail:liwp@lzu.edu.cn

Research advance of fascin expression in gynecological neoplasms

  • Received:2011-08-23 Revised:2011-12-02 Online:2012-08-05 Published:2012-07-17

摘要: 摘要:Fascin蛋白作为一种肌动蛋白结合蛋白,通过增加细胞膜突起、参与细胞信号传导通路以及改变细胞与细胞外基质的黏附等途径促进肿瘤细胞侵袭转移。与妇科恶性肿瘤的发生、组织分化、肿瘤分级和淋巴结转移等因素有关。Fascin蛋白有望成为判断妇科肿瘤患者预后的有效指标,以Fascin蛋白为靶点的治疗可能为妇科恶性肿瘤的治疗提供新的思路。

关键词: 关键词:Fascin, 妇科, 肿瘤

Abstract: Abstract: Fascin protein as a kind of actin-binding protein, by increasing the cell membrane bumps, participate in cell signaling pathways and changes in cell adhesion and extracellular matrix and other ways to promote tumor cell invasion and metastasis. It's related to tissue differentiation, tumor grade and lymph node metastasis and other factors of gynecological malignancies. Fascin protein is expected to be the effective judgment of prognosis of the patients of gynecological tumors. The fascin protein as a target for the treatment of gynecological cancer treatment may provide a new way of thinking.

Key words: Key words: Fascin, gynecological, neoplasm

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