基础医学与临床 ›› 2022, Vol. 42 ›› Issue (6): 960-963.doi: 10.16352/j.issn.1001-6325.2022.06.021

• 短篇综述 • 上一篇    下一篇

薯蓣皂苷防治原发性骨质疏松的研究进展

谢兴文1,2, 钟建春3*, 李鼎鹏1,2, 黄睿3, 李宁3, 郭云龙3, 翟伯宇3   

  1. 1.西北民族大学附属医院 骨科,甘肃 兰州 730030;
    2.甘肃省第二人民医院 骨科, 甘肃 兰州 730046;
    3.甘肃中医药大学 中医临床学院, 甘肃 兰州 730099
  • 收稿日期:2021-03-04 修回日期:2021-07-09 出版日期:2022-06-05 发布日期:2022-06-02
  • 通讯作者: * 1752709300@qq.com
  • 基金资助:
    国家自然科学基金(81860864);甘肃省科技计划(20JR5RA129);敦煌医学与转化教育部重点实验室开放课题(DHYX19-05);中央高校基本科研业务费项目(31920210041)

Research progress of dioscin in prevention and treatment of primary osteoporosis

XIE Xing-wen1,2, ZHONG Jian-chun3*, LI Ding-peng1,2, HUANG Rui3, LI Ning3, GUO Yun-long3, ZHAI Bo-yu3   

  1. 1. Department of Orthopaedics, the Affiliated Hospital of Northwest Minzu University, Lanzhou 730030;
    2. Department of Orthopaedics, the Second People's Hospital of Gansu Province, Lanzhou 730046;
    3. Clinical College of Chinese Medicine, Gansu University of Chinese Medicine,Lanzhou 730099,China
  • Received:2021-03-04 Revised:2021-07-09 Online:2022-06-05 Published:2022-06-02
  • Contact: * 1752709300@qq.com

摘要: 薯蓣皂苷具有较强的抗感染、抗病毒、降脂、抗癌、降糖、抗血栓、抗衰老和保肝等活性,可通过延迟氧化应激保护心脏细胞免受缺血/再灌注损伤,成为治疗冠心病和心绞痛的补充及替代临床药物之一。近年来的研究表明,薯蓣皂苷通过抑制核因子-κB受体活化因子配体(RANKL)诱导的破骨细胞分化和促进成骨细胞分化来防治骨质疏松症(OP)。本文综述了薯蓣皂苷在抑制破骨细胞、促进成骨及相关信号通路方面防治骨质疏松的研究进展,以期为薯蓣皂苷与药食同源在OP防治中的临床应用提供思路。

关键词: 薯蓣皂苷, 山药, 骨质疏松, 药食同源, 信号通路

Abstract: Dioscin has strong anti infection, anti-virus, lipid-lowering, anti-cancer, hypoglycemic, antithrombotic, anti-aging and liver protective activities. It can protect cardiac cells from ischemia/reperfusion injury by delaying oxidative stress, and become one of the complementary and alternative clinical drugs for the treatment of coronary heart disease and angina pectoris. In recent years, studies have shown that dioscin can prevent osteoporosis(OP) by inhibiting RANKL induced osteoclast differentiation and promoting osteoblast differentiation. This paper reviews the research progress of dioscin in the prevention and treatment of osteoporosis in the aspects of inhibiting osteoclasts, promoting osteogenesis and related signaling pathways, in order to provide ideas for the development of a nutrition-medicine hybyrid strategy in the prevention and treatment of OP.

Key words: dioscin, dioscorea opposita, osteoporosis, nutrition-medicine hybrid strategy, signal pathway

中图分类号: