基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 179-183.

• 短篇综述 • 上一篇    下一篇

环状RNAs在前列腺癌中的研究进展

冯天瑞1,严维刚2   

  1. 1. 中国医学科学院北京协和医院
    2. 中国医学科学院 北京协和医学院 北京协和医院
  • 收稿日期:2020-09-07 修回日期:2021-05-24 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: 严维刚 E-mail:ywgpumch@sina.com

Research progress of circular RNAs in prostate cancer

  • Received:2020-09-07 Revised:2021-05-24 Online:2022-01-05 Published:2022-01-05

摘要: 环状RNA(circRNAs)是一类有着独特的共价闭合环状结构的非编码RNA,其广泛存在于真核细胞中。近年来的研究表明circRNAs可通过调控microRNAs,与蛋白质结合,调节转录及剪接过程等方式参与包括恶性肿瘤在内的多种疾病的病理生理学过程。circRNAs特殊的结构和复杂的功能使其在肿瘤领域有着巨大的研究潜能。前列腺癌(PCa)是当今全球男性最高发的恶性肿瘤之一,目前对前列腺癌发生的机制及其诊治方案仍有待进一步深入研究。

关键词: 环状RNA, 前列腺癌, 基因调控

Abstract: Circular RNAs (circRNAs) are non-coding RNAs with unique covalently closed circular structures, which are widely found in eukaryotic cells. Recent studies have shown that circRNAs are involved in the pathophysiological processes of various diseases, including malignant tumors, by regulating microRNAs, binding to proteins, and regulating transcription and splicing processes. The special structure and complex functions of circRNAs make them have great research potential in the field of cancer. Prostate cancer is one of the most common malignancies among men in the world. At present, the pathogenesis and treatment of prostate cancer still need to be further studied.

Key words: circular RNA, prostate cancer, gene regulation

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