环状RNAs在前列腺癌中的研究进展

doi:10.16352/j.issn.1001-6325.2022.01.028

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 179-183.doi: 10.16352/j.issn.1001-6325.2022.01.028

环状RNAs在前列腺癌中的研究进展

冯天瑞, 严维刚^*

中国医学科学院北京协和医学院北京协和医院泌尿外科,北京 100730

收稿日期:2020-09-07 修回日期:2021-05-31 出版日期:2022-01-05 发布日期:2022-01-05
通讯作者: ^* ywgpumch@sina.com
基金资助:
国家自然科学基金国家重大科研仪器研制项目(21527801)

Research progress of circular RNAs in prostate cancer

FENG Tian-rui, YAN Wei-gang^*

Departments of Urology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing 100730,China

Received:2020-09-07 Revised:2021-05-31 Online:2022-01-05 Published:2022-01-05
Contact: ^* ywgpumch@sina.com

摘要/Abstract

摘要： 环状RNAs(circRNAs)是一类有着独特的共价闭合环状结构的非编码RNAs,其广泛存在于真核细胞中。近年来的研究表明circRNAs可通过调控microRNAs、与蛋白质结合、调节转录及剪接过程等方式参与包括恶性肿瘤在内的多种疾病的病理生理学过程。circRNAs特殊的结构和复杂的功能使其在肿瘤领域有着巨大的研究潜能。前列腺癌(PCa)是当今全球男性最高发的恶性肿瘤,目前对PCa发生的机制及其诊治方案仍有待进一步深入研究。

关键词: 环状RNA, 前列腺癌, 基因调控

Abstract: Circular RNAs (circRNAs) are non-coding RNAs with unique covalently closed circular structures and are widely found in eukaryotic cells. Recent studies have shown that circRNAs are involved in the patho-physiological processes of various diseases including malignant tumors through regulating microRNAs, binding to proteins and regulating transcription and splicing process. The special structure and complex functions of circRNAs make them have great research potential in the field of cancer. Prostate cancer(PCa) is one of the most common malignancies among the world. The the pathogenesis and treatment of PCa still need to be further studied.

Key words: circular RNAs, prostate cancer, gene regulation

中图分类号:

R737.25

冯天瑞, 严维刚. 环状RNAs在前列腺癌中的研究进展[J]. 基础医学与临床, 2022, 42(1): 179-183.

FENG Tian-rui, YAN Wei-gang. Research progress of circular RNAs in prostate cancer[J]. Basic & Clinical Medicine, 2022, 42(1): 179-183.

参考文献

[1]Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68:394-424.
[2]顾秀瑛,郑荣寿,张思维,等.2000-2014年中国肿瘤登记地区前列腺癌发病趋势及年龄变化分析[J].中华预防医学杂志,2018,52:586-592.
[3]Vo JN,Cieslik M,Zhang Y,et al.The landscape of circular RNA in cancer[J].Cell,2019,176:869-881.
[4]Hansen TB,Jensen TI,Clausen BH,et al.Natural RNA circles function as efficient microRNA sponges[J].Nature,2013,495:384-388.
[5]Kristensen LS,Hansen TB,Veno MT,et al.Circular RNAs in cancer:opportunities and challenges in the field[J].Oncogene,2018,37:555-565.
[6]Piwecka M,Glazar P,Hernandez-Miranda LR,et al.Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function[J].Science,2017,doi:10.1126/science.aam8526.
[7]Abdelmohsen K,Panda AC,Munk R,et al.Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1[J].RNA Biol,2017,14:361-369.
[8]Du WW,Fang L,Yang W,et al.Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity[J].Cell Death Differ,2017,24:357-370.
[9]Bach D,Lee SK,Sood AK.Circular RNAs in cancer[J].Mol Ther Nucleic Acids,2019,16:118-129.
[10]Kristensen LS,Andersen MS,Stagsted LVW,et al.The biogenesis,biology and characterization of circular RNAs[J].Nat Rev Genet,2019,20:675-691.
[11]Chen X,Han P,Zhou T,et al.circRNADb:a comprehen AR-V7 sive database for human circular RNAs with protein-coding annotations[J].Sci Rep,2016,6.
[12]Chen S,Huang V,Xu X,et al.Widespread and functional RNA circularization in localized prostate cancer[J].Cell,2019,176:831-843.
[13]Jin C,Zhao W,Zhang Z,et al.Silencing circular RNA circZNF609 restrains growth,migration and invasion by up-regulating microRNA-186-5p in prostate cancer[J].Artif Cells Nanomed Biotechnol,2019,47:3350-3358.
[14]Song Z,Zhuo Z,Ma Z,et al.Hsa_Circ_0001206 is downregulated and inhibits cell proliferation,migration and invasion in prostate cancer[J].Artif Cells Nanomed Biotechnol,2019,47:2449-2464.
[15]Yang Z,Qu C,Zhang Y,et al.Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway[J].Oncogene,2019,38:2516-2532.
[16]Huang C,Deng H,Wang Y,et al.Circular RNA circABCC4 as the ceRNA of miR-1182 facilitates prostate cancer progression by promoting FOXP4 expression[J].J Cell Mol Med,2019,23:6112-6119.
[17]Jie S,Cai Y,Feng T,et al.Upregulated circular RNA circ-102004 that promotes cell proliferation in prostate cancer[J].Int J Biol Macromol,2019,122:1235-1243.
[18]Feng Y,Yang Y,Zhao X,et al.Circular RNA circ0005276 promotes the proliferation and migration of prostate cancer cells by interacting with FUS to transcriptionally activate XIAP[J].Cell Death Dis,2019,doi:10.1038/s41419-019-2028-9.
[19]Cao B,Qi Y,Zhang G,et al.Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy[J].Oncotarget,2014,5:1646-1656.
[20]Antonarakis ES,Lu C,Wang H,et al.AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer[J].N Engl J Med,2014,371:1028-1038.
[21]Wu G,Sun Y,Xiang Z,et al.Preclinical study using circular RNA 17 and micro RNA 181c-5p to suppress the enzalutamide-resistant prostate cancer progression[J].Cell Death Dis,2019,doi:10.1038/s41419-018-1048-1.
[22]Shen Z,Zhou L,Zhang C,et al.Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel[J].Cancer Lett,2020,468:88-101.
[23]Luo J,Li Y,Zheng W,et al.Characterization of a prostate- and prostate cancer-specific circular RNA encoded by the androgen receptor gene[J].Mol Ther Nucleic Acids,2019,18:916-926.
[24]Cao S,Ma T,Ungerleider N,et al.Circular RNAs add diversity to androgen receptor isoform repertoire in castration-resistant prostate cancer[J].Oncogene,2019,38:7060-7072.
[25]Kong Z,Wan X,Lu Y,et al.Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR-29a-3p[J]. J Cell Mol Med,2020,24:799-813.

环状RNAs在前列腺癌中的研究进展

Research progress of circular RNAs in prostate cancer

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 9

编辑推荐

Metrics

本文评价

[1]	周智恩, 严维刚, 周毅, 左宇志, 梁震. 拼图(Jigasaw)教学法应用于前列腺靶向穿刺教学中的效果评估[J]. 基础医学与临床, 2022, 42(5): 844-847.
[2]	何啸, 胡为杰, 吕文昌, 任玉萍, 吴敏, 吴毅平, 张奇. 环状RNA在乳腺癌中作用的研究进展[J]. 基础医学与临床, 2022, 42(3): 507-511.
[3]	陈号, 陈韬, 吴静. IL-6/JAK/STAT3信号通路在前列腺癌发展和治疗中的研究进展[J]. 基础医学与临床, 2022, 42(1): 159-162.
[4]	李英杰, 杨庭楷, 纪志刚, 文进. 外泌体在前列腺癌诊疗中的研究进展[J]. 基础医学与临床, 2022, 42(1): 163-167.
[5]	程继付国赵华才王志刚高丹董青川. 姜黄素提高人前列腺癌细胞系PC-3放疗敏感性[J]. 基础医学与临床, 2021, 41(12): 1792-1796.
[6]	邓益斌农乐根梁祚仁张梁覃羽华何平. HCV LNAzyme对病毒5′非编码区基因调控的特异性抑制作用[J]. 基础医学与临床, 2014, 34(10): 1363-1366.
[7]	周智恩李汉忠严维刚. 雄激素受体蛋白表达及其基因获得/缺失与前列腺癌预后的相关性[J]. 基础医学与临床, 2010, 30(8): 857-861.
[8]	严维刚;李汉忠;周毅;崔全才. 前列腺癌空间分布特点的临床分析[J]. 基础医学与临床, 2010, 30(12): 1325-1328.
[9]	何旺祝志臻程志强王扬李鸣. PIAS3敲低对前列腺癌细胞增殖和凋亡的影响[J]. 基础医学与临床, 2008, 28(5): 469-472.