基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 15-25.

• 特邀专题 • 上一篇    下一篇

核壳结构树状大分子的设计及其生物医学应用

宋聪1,汪大圆1,沈明武1,史向阳1,2   

  1. 1. 东华大学 化学化工与生物工程学院
    2. 东华大学
  • 收稿日期:2021-12-03 修回日期:2021-12-03 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: 史向阳 E-mail:xshi@dhu.edu.cn

Design and biomedical applications of core-shell tecto dendrimers

  • Received:2021-12-03 Revised:2021-12-03 Online:2022-01-05 Published:2022-01-05

摘要: 核壳结构树状大分子(core-shell tecto dendrimers,CSTDs)是一类以相对高代树状大分子为核、相对低代树状大分子为壳的超结构树状大分子纳米体系。越来越多的研究表明,利用不同代的聚酰胺-胺(Poly(amidoamine),PAMAM)树状大分子作为反应模块构建的CSTDs不仅具有比相对高代树状大分子更优异的理化性能,还克服了单代树状大分子在医学应用上的一些局限性(如有限的载药量和EPR效应等)。在此,本文综述了近年来CSTDs的几种制备方法,并分类介绍了基于CSTDs的纳米平台在生物学成像、化疗、基因治疗以及联合治疗等方面的应用。最后,结合CSTDs研究现状分析了其当前在生物医学领域中的挑战和机遇。

Abstract: Core-shell tecto dendrimers (CSTDs) are a kind of superstructured dendrimeric nanoconstructs with relatively high-generation dendrimers as the cores and low-generation dendrimers as the shells. Recently, there is growing evidence that the performance of CSTDs constructed with poly(amidoamine) (PAMAM) dendrimers of different generations as reactive modules are not only superior to that of single-generation dendrimers, but also overcomes some biomedical limitations (e.g., restricted drug loading capacity, limited tumor passive targeting based on enhanced permeability and retention effect) of single-generation dendrimers. Herein, the design of CSTDs for biological imaging, chemotherapy, gene therapy, and combination therapy are reviewed. The current challenges and future development prospects of CSTDs in the field of biomedicine are also analyzed.